Fermentative Production of Natural Astaxanthin
Jan.15.2026
This project utilizes Haematococcus pluvialis as the production strain and employs a four-stage bioreactor system (50L, 500L, 5000L, and 35000L) to achieve large-scale fermentative production of natural astaxanthin. The core challenge addressed is the stage-specific control of algal cell proliferation versus astaxanthin accumulation, leading to highly efficient industrial output.
Process Flow follows a strict scale-up principle:
50L Lab-Scale Bioreactor: Responsible for seed activation and expansion. By precisely controlling temperature (20-25℃), optimal light (500-2000 Lux), and pH (7.5-8.0), a high-density, high-activity seed culture is prepared within 7 days.
500L Pilot-Scale Bioreactor: Transitions the seed culture to a larger volume. It focuses on optimizing Dissolved Oxygen (DO) and nutrient supply to ensure cell viability is maintained during scale-up.
5000L Transition-Scale Bioreactor: Completes mass cell proliferation, establishing a solid biomass foundation for large-scale production.
35000L Production-Scale Bioreactor: Implements the critical stress induction phase. By depleting nitrogen sources, increasing light intensity to over 10000 Lux, and raising the temperature to 28℃, the system forces the cells to accumulate astaxanthin efficiently.
Equipment Advantages are significant:
The full series of bioreactors are equipped with intelligent light and temperature control systems to perfectly match the requirements of the two-stage process. Optical sensors and precise feeding modules are integrated to monitor cell status in real-time, improving process control accuracy while effectively reducing the risk of microbial contamination.
Results:
The project achieved an astaxanthin content of over 3.0% of the cell dry weight. Furthermore, the energy consumption of the large-scale production process was reduced by 30% compared to traditional methods, providing high-purity natural astaxanthin raw materials for the food and health supplement industries.
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| Microbial Fermentation System | Process vessels | CIP Systems | Glass Fermentor |