Bioreactor Product Classification
Our Bioreactor Product Range: Tailored Solutions for Biopharmaceutical & Biotech Applications
As a leading supplier of bioreactors, we are committed to providing cutting-edge, customizable cell culture solutions that cater to the diverse needs of the biopharmaceutical, vaccine, and biotechnology industries. Our product portfolio is meticulously designed to support a wide spectrum of cell types—from mammalian and stem cells to plant cells, insect cells, and microorganisms—across laboratory research, pilot-scale development, and large-scale commercial production. Each bioreactor system integrates precise process control, advanced monitoring capabilities, and modular design to ensure optimal cell growth, high product yields, and compliance with global quality standards. Below is a detailed overview of our four core bioreactor product lines, highlighting their applications, key features, customization options, and proven success cases.
1. Glass Bioreactors
Applications & Key Features
Our Glass Bioreactors are versatile systems engineered for the cultivation of mammalian cells, stem cells, plant cells, and microorganisms. These reactors are equipped with state-of-the-art process control technology that enables precise regulation of critical culture parameters, including temperature, pH value, dissolved oxygen (DO) levels, aeration rate, and agitation speed. This precise control is fundamental to maintaining a stable and optimal growth environment for cells, which directly impacts cell viability and product quality.
A standout feature of our Glass Bioreactors is their flexible feeding and antifoaming capabilities, supporting both automatic and manual addition of nutrients, supplements, and antifoaming agents. This flexibility allows operators to adapt to different culture requirements and optimize feeding strategies based on real-time cell status. Additionally, the systems are integrated with advanced online monitoring tools that provide continuous real-time data on key process parameters. Operators can easily perform sampling without disrupting the culture environment, and the built-in data analysis功能 enables comprehensive evaluation of culture processes. Dynamic parameter adjustment is also supported, allowing for real-time optimization of culture conditions to maximize yields.
Customization Capabilities
We understand that different cell lines and microbial strains have unique culture requirements, which is why our Glass Bioreactors offer extensive customization options. Parameters can be tailored specifically to the characteristics of the cells or microorganisms being cultured, ensuring optimal growth and product expression. Furthermore, the reactors can be customized into multi-parallel systems (one-to-many parallel configuration) to meet the needs of high-throughput experiments, process optimization, and scale-up studies. Available parallel configurations include 2-parallel, 3-parallel, 4-parallel, 6-parallel, 8-parallel, and other custom configurations based on customer requirements. These parallel systems enable simultaneous cultivation under identical or varied conditions, significantly improving experimental efficiency and reducing development time.
Related Laboratory Bioreactors
In addition to standard glass bioreactors, our laboratory product range also includes specialized variants such as lab-scale glass bioreactors optimized for small-volume experiments (from a few liters to tens of liters) and fiber disk carrier bioreactors designed for adherent cell culture. These laboratory-scale systems retain the same high-precision control and monitoring capabilities as our larger systems, making them ideal for research and development, process optimization, and small-batch sample production.
2. Fiber disk Carrier Bioreactors
Core Applications & Technical Advantages
Our Fiber disk Carrier Bioreactors are specifically designed for the cultivation of adherent cells, such as animal cells and insect cells, in batch, fed-batch, or continuous perfusion modes. They are particularly well-suited for the production of secreted products, including recombinant proteins, viral vaccines, and therapeutic antibodies. The key innovation of these reactors lies in their unique fiber disk carrier design, which provides an ideal growth surface for adherent cells.
Cells are immobilized within the fibrous carriers, which effectively minimizes shear stress and bubble damage—two major challenges in adherent cell culture. This gentle culture environment enhances cell adhesion to the carrier surface, reduces cell detachment, and promotes long-term stable cell growth. As a result, these reactors achieve significantly higher product yields compared to traditional systems. Moreover, the reduced cell detachment leads to lower host cell DNA contamination in the harvested product, simplifying downstream purification processes and improving final product quality.
Proven Successful Projects
Our Fiber disk Carrier Bioreactors have a proven track record of success in numerous commercial and research projects, particularly in the vaccine industry. Key successful applications include:
Vero cell-based rabies vaccine and Inactivated Poliovirus Vaccine (IPV)
Vero cell-based Hantavirus vaccine
Vero cell-based Classical Swine Fever (CSF) vaccine
Vero cell-based porcine diarrhea vaccine
BSR cell-based veterinary rabies vaccine
MDCK cell-based influenza vaccine
CHO cell-based Erythropoietin (EPO) production
Diploid cell-based rabies vaccine
Specialized Application: Poliovirus Vaccine Production
A notable specialized application of our Fiber disk Carrier Bioreactors is in the production of poliovirus vaccine. The gentle culture environment, high cell density capabilities, and efficient product secretion support make these reactors an ideal choice for this critical vaccine production, ensuring consistent quality and high yields that meet global regulatory requirements.
3. Suspension Culture Bioreactors
Modular Design & Configuration Flexibility
Our Suspension Culture Bioreactors feature a modular design that offers a wide range of configurations, from basic functional setups to comprehensive, fully integrated systems. This modular approach allows us to provide tailored solutions that meet the specific budget and application requirements of each customer, whether for laboratory research, pilot-scale development, or large-scale commercial production.
The single skid culture volume ranges from 20 liters to 5000 liters, covering the entire spectrum of scale-up needs in biopharmaceutical production. These systems are capable of supporting cell seed expansion (from seed train to working cell bank), pilot-scale sample preparation (for preclinical and clinical trials), and large-scale commercial production (for market supply of vaccines, antibodies, and other biotherapeutics). The modular design also ensures easy scalability, allowing customers to expand their production capacity as their business grows, without the need for complete system replacement.
Key Applications & Successful Projects
Our Suspension Culture Bioreactors are widely used in the production of various biopharmaceutical products, with a strong track record of success in vaccine and antibody production. Key successful suspension culture projects include:
Foot-and-Mouth Disease (FMD) vaccine and Pseudorabies vaccine (using BHK cells)
Porcine Circovirus (PCV) vaccine (using High5 cells)
Avian Influenza vaccine (using MDCK cells)
Monoclonal antibodies (using CHO cells)
Rabies vaccine (using 293 cells)
Rabbit Hemorrhagic Disease (RHD) vaccine, Bovine Mastitis vaccine, and Classical Swine Fever (CSF) vaccine (using SF9 cells)
Case Study: Hangzhou Youben Animal Vaccine Project – Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine
A notable application case of our Suspension Culture Bioreactors is the Hangzhou Youben Animal Vaccine Project, where our systems are used for the production of porcine blue ear vaccine (PRRS vaccine). The modular design and precise process control of our bioreactors enabled Hangzhou Youben to achieve efficient, large-scale production of high-quality PRRS vaccine, meeting the growing demand for animal disease prevention in the livestock industry. The success of this project demonstrates our ability to provide reliable, scalable solutions for animal vaccine manufacturers.
4. Microcarrier Culture Bioreactors
Dual-Use Design & Key Features
Our Microcarrier Culture Bioreactors feature a unique, versatile design that supports both microcarrier-based cultivation of adherent cells and suspension cultivation of non-adherent cells. This dual-use capability makes them a cost-effective and flexible solution for customers who need to cultivate multiple cell types or switch between different culture modes. Like our other bioreactor systems, the Microcarrier Culture Bioreactors are modular and fully customizable, with skid volumes ranging from 20 liters to 5000 liters to accommodate various scale requirements.
A key advantage of these reactors is their low-shear stress design, which is critical for maintaining cell viability and promoting high-density cell growth. The optimized agitation and aeration systems minimize shear forces, protecting both adherent cells attached to microcarriers and non-adherent suspension cells. This design enables high-density, large-scale cell cultivation, with microcarrier densities reaching up to 20g/L and cell densities up to 1.5×10⁷ cells/ml. Such high cell densities directly translate to higher product yields, reducing production costs and improving process efficiency.
Proven Applications
Our Microcarrier Culture Bioreactors have been extensively validated in a wide range of biopharmaceutical applications, particularly in vaccine production. Proven successful applications include:
Vero cell-based rabies vaccine and IPV
293 cell-based rabies vaccine
Diploid cell-based rabies vaccine
ST cell-based Classical Swine Fever (CSF) vaccine
PK15 cell-based Porcine Circovirus (PCV) vaccine
Marc145 cell-based Porcine Reproductive and Respiratory Syndrome (PRRS) vaccine
50L Microcarrier Cell Culture Bioreactor
Among our Microcarrier Culture Bioreactor range, the 50L model is a popular choice for pilot-scale development and small-batch production. This system retains all the key features of our larger microcarrier reactors, including low-shear stress design, precise process control, and modular configuration, while being optimized for medium-scale applications. It is ideal for customers who are transitioning from laboratory-scale research to pilot-scale production, providing a reliable and scalable platform for process validation and sample preparation.
Why Choose Our Bioreactors?
At our company, we prioritize quality, flexibility, and customer satisfaction in every bioreactor system we design and manufacture. Our products are built to meet the strictest regulatory requirements (including cGMP) and are backed by comprehensive technical support and after-sales service. Key advantages of choosing our bioreactors include:
Precise process control: Advanced monitoring and control systems ensure stable culture conditions and consistent product quality.
Customization: Tailored configurations to meet specific cell type, scale, and application requirements.
Scalability: Modular design enables seamless scale-up from laboratory to commercial production.
Proven reliability: Extensive validation and successful application in numerous commercial projects.
Comprehensive support: Expert technical assistance, installation, training, and maintenance services.
Whether you are engaged in vaccine production, antibody development, or other biopharmaceutical applications, our bioreactor systems provide the performance, flexibility, and reliability you need to succeed in today's competitive biotechnology industry. Contact us today to learn more about how our tailored bioreactor solutions can support your specific needs.
